Lycopene's anti-cancer benefits extend to colon: study

Now, you have probably heard that lycopene is effective against certain types of cancers. Here is an article relating its benefits on the colon.

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The carotenoid lycopene from tomato may interfere with levels of a hormone associated with an increase in the risk of colorectal cancer, suggests a Dutch study. The randomised, placebo-controlled, double-blinded crossover study in 71 subjects showed that supplements of lycopene may increase levels of proteins that bind to insulin-like growth factor (IGF), linked with cancer risk.

The study, published late last year in the American Journal of Clinical Nutrition, extends our understanding of the potential anti-cancer benefits of lycopene, most notably linked to a lower risk of prostate cancer.

"This is the first study known to show that lycopene supplementation may increase circulating IGF-binding protein(BP)-1 and IGFBP-2 concentrations, thereby potentially decreasing IGF-I bioavailability," said lead author Alina Vrieling of the Netherlands Cancer Institute in Amsterdam.

"Thus, it may provide a means of ultimately reducing colorectal cancer risk, and potentially the risks of other major cancers such as prostate and pre-menopausal breast cancer."

Epidemiological evidence has suggested that tomato-based foods can protect men from prostate cancer. One study found that men eating four to five tomato based-dishes per week were 25 per cent less likely to develop prostate cancer compared to men eating tomatoes only rarely.

Such findings are boosting the lycopene market, with growth rates forecast at over 100 per cent by Frost and Sullivan, albeit from a low base of around €27m ($34m) in 2003.

Recently, researchers taking part in the Europe-wide European Prospective Investigation into Cancer and Nutrition (EPIC) reported that increased blood levels of lycopene may reduce the risk of advanced prostate cancer by 60 per cent.

"To our knowledge, this is the largest prospective study to date of plasma carotenoids, retinol, tocopherols, and prostate cancer risk,"American Journal of Clinical Nutrition (Vol. 86, pp. 672-681).

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